The effect of flurbiprofen and tiaprofenic acid on serum cytokine levels of patients with osteoarthrosis.
Acta Orthop Scand
; 72(5): 499-502, 2001 Oct.
Article
en En
| MEDLINE
| ID: mdl-11728078
39 patients with active knee osteoarthrosis, chosen according to ACR criteria, were assigned to receive flurbiprofen (n 12, 2 x 100 mg), tiaprofenic acid (n 14, 2 x 300 mg) and placebo (n 13) in a 3-week, placebo-controlled study. All patients completed the study, and both medications were found to be effective: improvement occurred in the clinical signs. These drugs reduced the TNF-alpha levels. Flurbiprofen especially affected the IL-6 levels. Our findings indicate that NSAIDs may be effective in the etiopathogenesis of osteoarthrosis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Propionatos
/
Antiinflamatorios no Esteroideos
/
Flurbiprofeno
/
Citocinas
/
Osteoartritis de la Rodilla
Tipo de estudio:
Clinical_trials
/
Observational_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Acta Orthop Scand
Año:
2001
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Reino Unido