A high density of X-linked genes for general cognitive ability: a run-away process shaping human evolution?
Trends Genet
; 17(12): 697-701, 2001 Dec.
Article
en En
| MEDLINE
| ID: mdl-11718922
The incidence of mental disability is 30% higher in males than in females. We have examined entries in the OMIM database that are associated with mental disability and for several other common defects. Our findings indicate that compared with the autosomes, the X chromosome contains a significantly higher number of genes that, when mutated, cause mental impairment. We propose that these genes are involved in the development of cognitive abilities and thus exert a large X-chromosome effect on general intelligence in humans. We discuss these conclusions with regard to the conservation of the vertebrate X-chromosomal linkage group and to human evolution.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cromosoma X
/
Cognición
/
Evolución Molecular
/
Inteligencia
/
Ligamiento Genético
/
Discapacidad Intelectual
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Trends Genet
Asunto de la revista:
GENETICA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Reino Unido