Microsatellite allelotyping of chinese nasopharyngeal carcinomas.
Anticancer Res
; 21(4B): 3081-4, 2001.
Article
en En
| MEDLINE
| ID: mdl-11712814
BACKGROUND: Chinese nasopharyngeal carcinoma (NPC) specimens were analyzed by microsatellite allelotyping to evaluate their usefulness as biomarkers for cancer detection. MATERIALS AND METHODS: A panel of eight microsatellite markers localized to chromosomes 3p, 6p, 9p, I1q and 14q were used to study 47 specimens. RESULTS: A moderately low loss of heterozygosity (LOH) frequency (8% to 35%) was observed; 23 (49%) specimens showed LOH with at least one marker while microsatellite instability (MSI) was detected in 10 specimens (21%). CONCLUSION: Poor survival was significantly associated with LOH detected by a chromosome 3 marker. Interestingly, tumors with multiple genetic alterations were significanty associated with earlier staging
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carcinoma
/
Neoplasias Nasofaríngeas
/
Cromosomas Humanos
/
Repeticiones de Microsatélite
/
Alelos
Tipo de estudio:
Evaluation_studies
/
Prognostic_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Anticancer Res
Año:
2001
Tipo del documento:
Article
Pais de publicación:
Grecia