[Activity of phosphodiesterases in granulation tissue treated with electron irradiation -- experimental study on rats]. / Atividade das fosfodiesterases em tecido de granulação submetido a irradiação de elétrons--estudo experimental em ratos.
Pesqui Odontol Bras
; 15(3): 223-8, 2001.
Article
en Pt
| MEDLINE
| ID: mdl-11705270
The present study evaluated the effect of low doses of electron radiation on the activity of phosphodiesterases in granulation tissue. In order to induce growth of granulation tissue, a PVC sponge disk was introduced under the dorsal skin of 84 Wistar rats. The rats were divided in two groups, control and irradiated. The enzymatic activity was evaluated according to the evolution of the granulation tissue after 5, 7, 10, 14, 17, 20 and 24 days. Irradiation was carried out 3 days after the implantation of the sponge, by means of a linear accelerator, with energy of 6 MeV, and dose of 1.0 Gy. The results of this study showed that 5'-nucleotidase and ATPase had their activity directly affected by irradiation only in the beginning of the tissue repairing process. Alkaline phosphatase did not suffer any direct effect of irradiation. It is possible that the main factor has been the damage of the cellular components responsible for the growth of granulation tissue, which determine the production of enzymes according to the necessity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Partículas beta
/
Hidrolasas Diéster Fosfóricas
/
Tejido de Granulación
Límite:
Animals
Idioma:
Pt
Revista:
Pesqui Odontol Bras
Asunto de la revista:
ODONTOLOGIA
Año:
2001
Tipo del documento:
Article
Pais de publicación:
Brasil