Comprehensive analysis of a large genomic sequence at the putative B-cell chronic lymphocytic leukaemia (B-CLL) tumour suppresser gene locus.
Mutat Res
; 458(3-4): 55-70, 2001 Dec.
Article
en En
| MEDLINE
| ID: mdl-11691637
In many haematological diseases, and more particularly in B-cell chronic lymphocytic leukaemia (B-CLL), the existence of a tumour suppressor gene located within the frequently deleted region 13q14.3, has been put forward. A wide candidate region spanning from marker D13S273 to D13S25 has been proposed and an extensive physical map has been constructed by several teams. In this study, we sequenced a minimal core deleted region that we have previously defined and annotated it with flanking available public sequences. Our analysis shows that this region is gene-poor. Furthermore, our work allowed us to identify new alternative transcripts, spanning core regions, of the previously defined candidate genes DLEU1 and DLEU2. Since their putative involvement in B-CLL was controversial, our present study provide support for reconsidering the DLEU1 and DLEU2 genes as B-CLL candidate genes, with a new definition of their organisation and context.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos B
/
Leucemia Linfocítica Crónica de Células B
/
Genes Supresores de Tumor
/
Eliminación de Secuencia
Límite:
Humans
Idioma:
En
Revista:
Mutat Res
Año:
2001
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Países Bajos