Effects of HRT on serum levels of IGF-I in postmenopausal women.
Maturitas
; 40(1): 69-74, 2001 Oct 31.
Article
en En
| MEDLINE
| ID: mdl-11684375
OBJECTIVES: It is thought that insulin-like growth factor-1 (IGF-I) stimulates bone formation. We aimed to determine the effects of oral and transdermal hormone replacement therapy (HRT) on serum IGF-I levels and to investigate the effects of basal IGF-I levels on the levels obtained at the end of the therapy. METHODS: Sixty-six postmenopausal women were administered either oral (n=44) or transdermal (n=22) HRT for 6 months. Serum levels of IGF-I were determined before and after HRT in all subjects. Groups were divided into two subgroups according to the median value of serum IGF-I levels (basal IGF-I levels above or below the median value). The increase of IGF-I levels after HRT were calculated (%) for all women. Mean increases of subgroups were compared. Furthermore, study groups were divided into three subgroups according to the changing of IGF-I (increase>25%, between 25% increase and 25% decrease and decrease>25%). Mean basal IGF-I levels of these three subgroups were compared. RESULTS: Mean serum levels of IGF-I before and after HRT were not significantly different in both oral and transdermal groups (P>0.05). Mean increases of IGF-I after HRT for the patients with low basal IGF-I levels, were 65% in oral and 77% in transdermal groups. However, mean increase of the patients with high basal IGF-I levels were -8 and -16% respectively. Moreover, mean level of basal IGF-I was significantly low in women who have more than a 25% increase after HRT (P<0.05). CONCLUSION: HRT seems to significantly increase serum levels of IGF-I in postmenopausal women with low basal levels of IGF-I.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factor I del Crecimiento Similar a la Insulina
/
Terapia de Reemplazo de Estrógeno
/
Posmenopausia
/
Estradiol
/
Noretindrona
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Maturitas
Año:
2001
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Irlanda