The main biological determinants of tumor line taxonomy elucidated by a principal component analysis of microarray data.
FEBS Lett
; 507(1): 114-8, 2001 Oct 19.
Article
en En
| MEDLINE
| ID: mdl-11682069
By using principal components analysis (PCA) we demonstrate here that the information relevant to tumor line classification linked to the activity of 1375 genes expressed in 60 tumor cell lines can be reproduced by only five independent components. These components can be interpreted as cell motility and migration, cellular trafficking and endo/exocytosis, and epithelial character. PCA, at odds with cluster analysis methods routinely used in microarray analysis, allows for the participation of individual genes to multiple biochemical pathways, while assigning to each cell line a quantitative score reflecting fundamental biological functions.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Tumorales Cultivadas
Límite:
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
2001
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Reino Unido