Fetal growth and urinary albumin excretion among middle-aged Danes.
Scand J Urol Nephrol
; 35(4): 314-8, 2001 Sep.
Article
en En
| MEDLINE
| ID: mdl-11676359
OBJECTIVE: Impaired fetal growth has been linked with cardiovascular disease and different cardiovascular risk factors. Few studies have examined the association between fetal growth and urinary albumin excretion, an important predictor of vascular disease in both diabetic and non-diabetic subjects. MATERIAL AND METHODS: We examined the association between markers of fetal growth, ie, birth weight, birth length and Ponderal Index, from birth records and urinary albumin excretion in 545 middle-aged men and women who had taken part in a population-based follow-up study in the municipality of Ebeltoft, Denmark. The outcome was the urinary albumin-creatinine ratio. RESULTS: Three men (1.1%) and 10 women (3.6%) had a albumin-creatinine ratio above 2.5/3.5 mg/mmol, which is considered abnormal and diagnostic of microalbuminuria. The strength of the associations between birth weight, birth length, Ponderal Index and albumin-creatinine ratio were fitted in separate multivariate models, but no associations were found in any model. CONCLUSIONS: Our study did not support the hypothesis of an association between fetal growth and adult albumin-creatinine ratio. Studies with larger numbers of microalbuminuric subjects are required in order to further clarify the relationship between fetal growth and later renal function.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Constitución Corporal
/
Albuminuria
/
Desarrollo Embrionario y Fetal
Tipo de estudio:
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Límite:
Female
/
Humans
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Male
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Middle aged
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Newborn
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Pregnancy
País/Región como asunto:
Europa
Idioma:
En
Revista:
Scand J Urol Nephrol
Año:
2001
Tipo del documento:
Article
País de afiliación:
Dinamarca
Pais de publicación:
Reino Unido