Fish oil supplementation improves visual evoked potentials in children with phenylketonuria.

Beblo, S; Reinhardt, H; Muntau, A C; Mueller-Felber, W; Roscher, A A; Koletzko, B

Beblo, S; Reinhardt, H; Muntau, A C; Mueller-Felber, W; Roscher, A A; Koletzko, B.

Afiliación

Beblo S; Division of Metabolic Diseases and Nutrition, Dr. von Haunersches Kinderspital, Munich, Germany.

Neurology ; 57(8): 1488-91, 2001 Oct 23.

Article en En | MEDLINE | ID: mdl-11673596

RESUMEN

Visual evoked potentials (VEP) were measured in 36 patients with early-treated phenylketonuria (PKU; aged 1 to 11 years) and good metabolic control before and after supplementation with omega-3 long-chain polyunsaturated fatty acids (LC-PUFA) from fish oil. Patients with PKU had significantly longer P100 latencies than 22 age-matched control subjects. After 3 months of LC-PUFA supplementation, VEP latencies improved significantly in PKU patients but did not change in 12 untreated healthy children. The authors conclude that omega-3 LC-PUFA are essential substrates for nervous system function even beyond infancy.

Asunto(s)

Potenciales Evocados Visuales/efectos de los fármacos; Aceites de Pescado/uso terapéutico; Fenilcetonurias/tratamiento farmacológico; Niño; Preescolar; Ácidos Grasos Omega-3/uso terapéutico; Humanos; Lactante; Fenilcetonurias/fisiopatología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenilcetonurias / Aceites de Pescado / Potenciales Evocados Visuales Tipo de estudio: Clinical_trials Límite: Child / Child, preschool / Humans / Infant Idioma: En Revista: Neurology Año: 2001 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos

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