Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung.
Nat Immunol
; 2(11): 1067-76, 2001 Nov.
Article
en En
| MEDLINE
| ID: mdl-11668342
A potent role for memory CD8+ T cells in heterologous immunity was shown with a respiratory mucosal model of viral infection. Memory CD8+ T cells generated after lymphocytic choriomeningitis virus (LCMV) infection were functionally activated in vivo to produce interferon-gamma (IFN-gamma) during acute infection with vaccinia virus (VV). Some of these antigen-specific memory cells selectively expanded in number, which resulted in modulation of the original LCMV-specific T cell repertoire. In addition, there was an organ-selective compartmental redistribution of these LCMV-specific T cells during VV infection. The presence of these LCMV-specific memory T cells correlated with enhanced VV clearance, decreased mortality and marked changes in lung immunopathology. Thus, the participation of pre-existing memory T cells specific to unrelated agents can alter the dynamics of mucosal immunity and disease course in response to a pathogen.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones del Sistema Respiratorio
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Vaccinia
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Virus Vaccinia
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Subgrupos de Linfocitos T
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Linfocitos T CD8-positivos
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Memoria Inmunológica
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Pulmón
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Coriomeningitis Linfocítica
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Virus de la Coriomeningitis Linfocítica
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Mucosa Nasal
Límite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Nat Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos