The effect of progestin R 2323 released from vaginal rings on ovarian function.
Contraception
; 12(3): 299-307, 1975 Sep.
Article
en En
| MEDLINE
| ID: mdl-1164848
PIP: The effect of progestin R 2323 released from intravaginal rings (IVR) on ovarian function was studied in 20 young healthy volunteers. The silastic IVRs containing 10, 20, 50, or 200 mg of progestin R 2323 were inserted on the 1st day after menstrual bleeding and removed 21 days after insertion. The IVRs were tolerated well without irritation or alteration of the vaginal mucosa. Control plasma estradiol and progesterone levels revealed 18 of 20 cycles were ovulatory. No ovulation was observed during treatment, as revealed by consistently suppressed progesterone levels. Normal ovulation resumed after removal of the rings. 3 women experienced withdrawal bleeding; 9 had breakthrough bleeding and 13 had a normal postovulatory bleeding 15-33 days after ring removal. It was concluded that the bleeding control was unsatisfactory with every dosage of R 2323 used in this study.^ieng
Palabras clave
Biology; Bleeding; Clinical Research; Contraception; Contraceptive Agents, Female--side effects; Contraceptive Agents, Progestin--side effects; Contraceptive Agents--side effects; Diseases; Endocrine System; Family Planning; Genitalia; Genitalia, Female; Hormones; Metrorrhagia--etiology; Ovarian Effects; Ovary; Physiology; Progestational Hormones; Progesterone--analysis; Progestins, Low-dose--side effects; Research Methodology; Reversibility; Signs And Symptoms; Urogenital System; Vagina; Vaginal Abnormalities; Vaginal Desquamate Effects; Vaginitis
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ovario
/
Norgestrienona
/
Norpregnatrienos
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Contraception
Año:
1975
Tipo del documento:
Article
Pais de publicación:
Estados Unidos