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Genetic, physical, and phenotypic characterization of the Del(13)Svea36H mouse.
Arkell, R M; Cadman, M; Marsland, T; Southwell, A; Thaung, C; Davies, J R; Clay, T; Beechey, C V; Evans, E P; Strivens, M A; Brown, S D; Denny, P.
Afiliación
  • Arkell RM; MRC UK Mouse Genome Centre & Mammalian Genetics Unit Harwell, Oxon, OX11 0RD, UK.
Mamm Genome ; 12(9): 687-94, 2001 Sep.
Article en En | MEDLINE | ID: mdl-11641716
The Del(13)Svea36H deletion was recovered from a radiation mutagenesis experiment and represents a valuable resource for investigating gene content and function at this region of mouse Chromosome (Chr) 13 and human Chr 6p21.3-23 and 6p25. In this paper we examine the physical extent of chromosome loss and construct an integrated genetic and radiation hybrid map of the deleted segment. We show that embryos which are homozygous for the deletion die at or before implantation and that heterozygotes are subviable, with a substantial proportion of carriers dying after mid-gestation but before weaning. The majority of viable carriers exhibit a variety of phenotypes including decreased size, eyes open at birth, corneal opacity, tail kinks, and craniofacial abnormalities. Both the heterozygous viability and the penetrance of the visible phenotypes vary with genetic background.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deleción Cromosómica / Cromosomas Límite: Animals Idioma: En Revista: Mamm Genome Asunto de la revista: GENETICA Año: 2001 Tipo del documento: Article Pais de publicación: Estados Unidos
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deleción Cromosómica / Cromosomas Límite: Animals Idioma: En Revista: Mamm Genome Asunto de la revista: GENETICA Año: 2001 Tipo del documento: Article Pais de publicación: Estados Unidos