The role of cytochrome P450-mediated drug-drug interactions in determining the safety of statins.
Expert Opin Pharmacother
; 2(7): 1119-27, 2001 Jul.
Article
en En
| MEDLINE
| ID: mdl-11583063
The objectives of this review are to discuss the role of cytochrome P450 (CYP450) isoforms in drug metabolism, to explain differences in metabolism among the HMG-CoA reductase inhibitors (HMGs, statins), to review drug-drug and drug-food interaction studies dealing with the HMGs, to present case reports dealing with HMG-related myopathy, to discuss major clinical implications of these case reports and to express an opinion of use of HMGs in clinical practice.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inhibidores de Hidroximetilglutaril-CoA Reductasas
/
Sistema Enzimático del Citocromo P-450
/
Inhibidores Enzimáticos
/
Hipolipemiantes
Tipo de estudio:
Guideline
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Expert Opin Pharmacother
Asunto de la revista:
FARMACOLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido