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A weakly antimalarial biflavanone from Rhus retinorrhoea.
Ahmed, M S; Galal, A M; Ross, S A; Ferreira, D; ElSohly, M A; Ibrahim, A S; Mossa, J S; El-Feraly, F S.
Afiliación
  • Ahmed MS; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Phytochemistry ; 58(4): 599-602, 2001 Oct.
Article en En | MEDLINE | ID: mdl-11576606
The biflavanone (2S,2"S)-7,7"-di-O-methyltetrahydroamentoflavone and five known flavonoids, 7-O-methylnaringenin, 7,3'-O-dimethylquercetin, 7-O-methylapigenin, 7-O-methylluteolin, and eriodictyol were isolated from the leaves of Rhus retinorrhoea Steud, Ex Olive. The biflavanone exhibited moderate antimalarial activity with IC50 0.98 microg/ml against Plasmodium falciparum (W2 Clone) and weak activity against P. falciparum (D6 Clone) with IC50 2.8 microg/ml. Nevertheless, it did not display any cytotoxicity. 7-O-Methylnaringenin showed weak antimicrobial activity against Candida albicans, C. krusei, Staphylococcus aureus, Mycobacterium smegmatis, M. intracellulare, and M. xenopi with MIC approximately 100 microg/ml. Characterization of each compound was based on spectral analysis and comparison with reported data.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flavonoides / Rhus / Biflavonoides / Antiinfecciosos / Antimaláricos Límite: Animals Idioma: En Revista: Phytochemistry Año: 2001 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Reino Unido
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flavonoides / Rhus / Biflavonoides / Antiinfecciosos / Antimaláricos Límite: Animals Idioma: En Revista: Phytochemistry Año: 2001 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Reino Unido