Virus-induced autoimmunity: potential role of viruses in initiation, perpetuation, and progression of T-cell-mediated autoimmune disease.

Olson, J K; Croxford, J L; Miller, S D

Olson, J K; Croxford, J L; Miller, S D.

Afiliación

Olson JK; Department of Microbiology-Immunology and the Interdepartmental Immunobiology Center, Northwestern University Medical School, Chicago, Illinois 60611, USA.

Viral Immunol ; 14(3): 227-50, 2001.

Article en En | MEDLINE | ID: mdl-11572634

RESUMEN

Virus infections have been implicated in the initiation of multiple human autoimmune diseases. This article focuses on reviewing the role of viruses in initiation, progression, and perpetuation of autoimmune diseases. Various mechanisms by which virus infections can induce autoimmune responses including molecular mimicry, epitope spreading, direct bystander activation, and release of cryptic epitopes are discussed. Evidence implicating virus infections in the pathogenesis of various human autoimmune diseases is reviewed. Last, the characteristics of animal models that have been developed for the study of the potential role of viruses in the initiation and progression of autoimmune disease are reviewed.

Asunto(s)

Enfermedades Autoinmunes/etiología; Autoinmunidad/inmunología; Virosis/complicaciones; Virus/patogenicidad; Adulto; Animales; Enfermedades Autoinmunes/inmunología; Modelos Animales de Enfermedad; Humanos; Ratones; Ratones Endogámicos C57BL

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Virus / Virosis / Autoinmunidad Tipo de estudio: Prognostic_studies Límite: Adult / Animals / Humans Idioma: En Revista: Viral Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA / VIROLOGIA Año: 2001 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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