Osteosarcoma cell apoptosis induced by selenium.

Hiraoka, K; Komiya, S; Hamada, T; Zenmyo, M; Inoue, A

Hiraoka, K; Komiya, S; Hamada, T; Zenmyo, M; Inoue, A.

Afiliación

Hiraoka K; Department of Orthopaedic Surgery, Kurume University School of Medicine, Japan.

J Orthop Res ; 19(5): 809-14, 2001 Sep.

Article en En | MEDLINE | ID: mdl-11562125

RESUMEN

An essential nutrient selenium has been reported to be a potential cancer preventive and inhibitory agent, although no exact mechanism has yet been proposed. Since little is known about the anti-proliferative effect of selenium on osteosarcoma, this issue was addressed in the present study in vitro using three osteosarcoma cell lines, and in vivo using an osteosarcoma transplantable to nude mice. Selenium inhibited the tumor growth in vitro and morphological changes indicative of apoptosis were demonstrated. Osteosarcomas in nude mice were inhibited in growth by selenium with no cytotoxic change in normal tissues. The findings suggested that selenium may offer a novel therapeutic modality for osteosarcoma.

Asunto(s)

Apoptosis/efectos de los fármacos; Neoplasias Óseas/tratamiento farmacológico; Osteosarcoma/tratamiento farmacológico; Selenio/farmacología; Animales; División Celular/efectos de los fármacos; Humanos; Técnicas In Vitro; Ratones; Ratones Desnudos; Trasplante de Neoplasias; Fase S/efectos de los fármacos; Células Tumorales Cultivadas/citología; Células Tumorales Cultivadas/efectos de los fármacos; Células Tumorales Cultivadas/trasplante

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Selenio / Neoplasias Óseas / Osteosarcoma / Apoptosis Límite: Animals / Humans Idioma: En Revista: J Orthop Res Año: 2001 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos

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