Molecular pathology of pancreatic cancer.

Hruban, R H; Iacobuzio-Donahue, C; Wilentz, R E; Goggins, M; Kern, S E

Hruban, R H; Iacobuzio-Donahue, C; Wilentz, R E; Goggins, M; Kern, S E.

Afiliación

Hruban RH; Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

Cancer J ; 7(4): 251-8, 2001.

Article en En | MEDLINE | ID: mdl-11561601

RESUMEN

Until recently, pancreatic cancer was a poorly understood disease. Research in the past decade has shown conclusively, however, that pancreatic cancer is primarily genetic in nature. Inactivation with a variety of tumor-suppressor genes such as p16, DPC4, and p53, coupled with activation of oncogenes such as K-ras, are a few of the mutations that trigger the growth of cancerous cells. Understanding these mutations is critical to a better understanding of familial pancreatic cancer and to the development of gene-based screening tests and therapies. In this article, we review the genetic alterations identified in pancreatic cancer and provide examples of how this information can be applied to patient care.

Asunto(s)

ADN Mitocondrial/genética; Genes Supresores de Tumor/fisiología; Oncogenes/fisiología; Neoplasias Pancreáticas/genética; Humanos; Neoplasias Pancreáticas/enzimología; Neoplasias Pancreáticas/patología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oncogenes / Neoplasias Pancreáticas / ADN Mitocondrial / Genes Supresores de Tumor Límite: Humans Idioma: En Revista: Cancer J Asunto de la revista: NEOPLASIAS Año: 2001 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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