Tubulointerstitial nephritis and uveitis syndrome in two siblings.

Tanaka, H; Waga, S; Nakahata, T; Suzuki, K; Ito, T; Onodera, N; Iwami, S; Monma, N; Ito, E

Tanaka, H; Waga, S; Nakahata, T; Suzuki, K; Ito, T; Onodera, N; Iwami, S; Monma, N; Ito, E.

Afiliación

Tanaka H; Department of Pediatrics, Hirosaki University School of Medicine, Japan. hirotana@cc.hirosaki-u.ac.jp

Tohoku J Exp Med ; 194(1): 71-4, 2001 May.

Article en En | MEDLINE | ID: mdl-11556736

RESUMEN

Two Japanese sisters with persistent uveitis showed significant increased levels of urinary beta-2 microglobulin. A percutaneous renal biopsy performed in the younger sister revealed tubulointerstitial nephritis (TIN) with helper/inducer T cell infiltrates. Also, abnormal 67-gallium accumulation in the kidneys, suggesting TIN, was observed in the other one at the same time. Although patients with the syndrome of tubulointerstitial nephritis and uveitis (TINU) have been reported to date, its occurrence in siblings has rarely been seen. Both of them shared same human leukocyte antigen (HLA) DR6, suggesting the potential association between HLA-DR6 and TINU.

Asunto(s)

Antígeno HLA-DR6/inmunología; Nefritis Intersticial/inmunología; Uveítis/inmunología; Adolescente; Niño; Femenino; Humanos; Nefritis Intersticial/tratamiento farmacológico; Nefritis Intersticial/patología; Nefritis Intersticial/fisiopatología; Núcleo Familiar; Uveítis/fisiopatología

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Uveítis / Antígeno HLA-DR6 / Nefritis Intersticial Límite: Adolescent / Child / Female / Humans Idioma: En Revista: Tohoku J Exp Med Año: 2001 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links