Comparative study of the immune response in mice immunized with four live attenuated strains of mumps virus by intranasal or intramuscular route.
Arch Virol
; 146(7): 1241-8, 2001 Jul.
Article
en En
| MEDLINE
| ID: mdl-11556703
The observation of many cases of mumps and mumps-associated CNS complications in vaccinees prompted us to perform an evaluation of the efficacy of four attenuated mumps virus (Urabe, Jeryl Lynn, Rubini and S12) vaccines. Two doses of vaccine were necessary to induce a good immunity in animals. The humoral and cell-mediated response induced in mice immunized intramuscularly or intranasally with these vaccines has been evaluated. Although the Urabe and Jeryl Lynn strains appear more immunogenic than the other strains and induce higher levels of IgG when administered intramuscularly, the S-12 strain administered intranasally induces a good IgG response. A marked specific CTL activity against mumps virus was observed in mice immunized intranasally with all the strains and, particularly, with the S12 strain. Thus, the intranasal immunization could be considered a possible alternative and efficient route of vaccination against mumps.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vacuna contra la Parotiditis
/
Linfocitos T Citotóxicos
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Vacunación
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Rubulavirus
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Anticuerpos Antivirales
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Paperas
Límite:
Animals
Idioma:
En
Revista:
Arch Virol
Año:
2001
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Austria