The nitric oxide synthase inhibitor, L-NAME, block phencyclidine-induced disruption of prepulse inhibition in mice.
Psychopharmacology (Berl)
; 156(2-3): 182-6, 2001 Jul.
Article
en En
| MEDLINE
| ID: mdl-11549221
RATIONALE: Schizophrenia is a major public health problem that affects approximately 1% of the population worldwide. Schizophrenia-like syndromes can be induced in humans by phencyclidine (PCP), a drug with marked psychomimetic properties. Recent studies show that the behavioural and biochemical effects of PCP in rats are blocked by nitric oxide synthase (NOS) inhibitors, suggesting that NO plays an important role in the pharmacological effects of PCP. OBJECTIVE: The aim of this study was to investigate if PCP-induced disruption of prepulse inhibition of acoustic startle could be blocked by the NOS inhibitor, L-NAME, in mice. RESULTS: The present study shows that PCP readily disrupts prepulse inhibition in mice normally without affecting pulse-alone trials. Furthermore, L-NAME blocked the PCP-induced disruption of prepulse inhibition in a dose-related manner. CONCLUSIONS: The PCP-induced disruption of prepulse inhibition and the ability of L-NAME to block this effect in both rats and mice suggest that this is a general and not a species-specific effect. The results of the present study further suggest that PCP exerts at least some of its actions in the central nervous system by a NO-dependent mechanism.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fenciclidina
/
Reflejo de Sobresalto
/
Óxido Nítrico Sintasa
/
NG-Nitroarginina Metil Éster
/
Inhibidores Enzimáticos
/
Alucinógenos
Límite:
Animals
Idioma:
En
Revista:
Psychopharmacology (Berl)
Año:
2001
Tipo del documento:
Article
País de afiliación:
Suecia
Pais de publicación:
Alemania