Sphingolipid derivatives modulate intracellular Ca2+ in rat synaptosomes.
Acta Neurobiol Exp (Wars)
; 61(2): 113-7, 2001.
Article
en En
| MEDLINE
| ID: mdl-11512408
Sphingosylphosphorylcholine (SPC) induces a rapid increase of intracellular Ca2+ concentration in isolated synaptosomes. This effect is dose-dependent and is also dependent on extracellular Ca2+. Sphingosine (SPH) has a smaller effect and treatment with psychosine (PSY) is ineffective, which suggests that phosphorylation of the 1-carbon of SPH is required for the SPC to act as a Ca2+ release agonist in synaptosomes. Experiments performed in the presence of heparin or ryanodine indicate that SPC-elicited Ca2+ release is not mediated by IP3 or ryanodine receptors. Finally, our results show that the effect of SPC on Ca2+ concentration is nimodipine-sensitive, suggesting that SPC possibly activates a specific sphingolipid-gated Ca2+ channel in synaptosomes.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosforilcolina
/
Esfingolípidos
/
Esfingosina
/
Sinaptosomas
/
Calcio
Límite:
Animals
Idioma:
En
Revista:
Acta Neurobiol Exp (Wars)
Año:
2001
Tipo del documento:
Article
País de afiliación:
España
Pais de publicación:
Polonia