Effects of ageing on serotonin transporters in healthy females.
Eur J Nucl Med
; 28(7): 911-3, 2001 Jul.
Article
en En
| MEDLINE
| ID: mdl-11504089
The effect of ageing on brain serotonin transporters was evaluated in 19 healthy female volunteers (age range 22-74 years) using single-photon emission tomography and [123I]nor-beta-CIT. The study subjects were scanned 0.3, 3, 6 and 23 h after injection of 185 MBq of [123I]nor-beta-CIT. The ratio of the distribution volume for tracer in the midbrain to that in the cerebellum minus 1 was used as an index for serotonin transporter binding. An age-related decline of 2% per decade (r=-0.47; P<0.05) was found in the midbrain. The decline in [123I]nor-beta-CIT binding in the serotonin transporter-rich area is much less than that in dopamine transporters in the striatum (6% per decade).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas de Transporte de Membrana
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Encéfalo
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Envejecimiento
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Glicoproteínas de Membrana
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Proteínas Portadoras
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Serotonina
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Tomografía Computarizada de Emisión de Fotón Único
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Caracteres Sexuales
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Cocaína
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Proteínas del Tejido Nervioso
Límite:
Adult
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Aged
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Eur J Nucl Med
Año:
2001
Tipo del documento:
Article
País de afiliación:
Finlandia
Pais de publicación:
Alemania