The long-term response to levodopa in dopa-responsive dystonia.
Parkinsonism Relat Disord
; 8(1): 1-5, 2001 Sep.
Article
en En
| MEDLINE
| ID: mdl-11472874
We report the long-term response to levodopa in 20 patients with dopa-responsive dystonia (DRD). We found an inverse correlation between the daily dose of levodopa and duration of treatment (r=-0.59, P<0.01). Mild dyskinesias were present in 20% of our patients. Dyskinetic patients were on a higher dose of levodopa than non-dyskinetics. Dyskinesias responded to a reduction in levodopa, with no deterioration in motor function. We propose that the dopamine turnover might decrease with time, which would lead to a decrease in the requirement for levodopa and the occurrence of dyskinesias late in the course of DRD.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dopaminérgicos
/
Dihidroxifenilalanina
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Levodopa
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Distonía
Tipo de estudio:
Observational_studies
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Parkinsonism Relat Disord
Asunto de la revista:
NEUROLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
Reino Unido