Neonatal salivary cortisol in response to heelstick: method modifications enable analysis of low concentrations and small sample volumes.
Scand J Clin Lab Invest
; 61(4): 287-91, 2001 Jul.
Article
en En
| MEDLINE
| ID: mdl-11465342
Measuring cortisol in saliva offers important advantages compared to measurement in plasma or serum. However, the sampling procedure and also the detection limit cause problems, especially in paediatric and neonatal care. We describe a simple and efficient sampling procedure, together with a modification of a radioimmunoassay, which enables analysis of low (down to 1 nmol/L) concentrations of salivary cortisol (10 times lower detection limit than in the original procedure). This setting was used in studying salivary cortisol concentrations before and after heelstick on healthy newborn infants. A significant rise (median 81%; p<0.01) in salivary cortisol as response to this invasive stressor was noted.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Saliva
/
Estrés Fisiológico
/
Hidrocortisona
/
Radioinmunoensayo
Límite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
Scand J Clin Lab Invest
Año:
2001
Tipo del documento:
Article
País de afiliación:
Suecia
Pais de publicación:
Reino Unido