Ethnic differences in distributions of GSTM1 and GSTT1 homozygous "null" genotypes in India.
Hum Biol
; 73(3): 443-50, 2001 Jun.
Article
en En
| MEDLINE
| ID: mdl-11459424
We estimated the frequencies of GSTM1 and GSTT1 "null" homozygotes in 10 different ethnic populations of India by a genotyping method based on polymerase chain reaction. These populations, inhabiting diverse geographical locations and occupying various positions in the sociocultural hierarchy, were represented by a sample of 299 unrelated individuals. Frequencies of GSTM1 and GSTT1 "null" homozygotes varied from 20% to 79% and 3% to 39%, respectively, across the study populations. Maximum frequencies of GSTM1 and GSTT1 "null" homozygotes (79% and 39%, respectively) have been observed in the same population (Jamatia). Frequencies of homozygous "null" genotypes at the GSTM1 and GSTT1 loci show a significant positive correlation in these populations, which is contrary to expectations. A possible implication is that the two enzymes are working in tandem, instead of working in a complementary way.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Clase Social
/
Etnicidad
/
Glutatión Transferasa
Tipo de estudio:
Diagnostic_studies
Aspecto:
Determinantes_sociais_saude
/
Equity_inequality
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Hum Biol
Año:
2001
Tipo del documento:
Article
Pais de publicación:
Estados Unidos