Structures of cordypyridones A-D, antimalarial N-hydroxy- and N-methoxy-2-pyridones from the insect pathogenic fungus Cordyceps nipponica.

Isaka, M; Tanticharoen, M; Kongsaeree, P; Thebtaranonth, Y

Isaka, M; Tanticharoen, M; Kongsaeree, P; Thebtaranonth, Y.

Afiliación

Isaka M; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Bangkok 10400, Thailand. isaka@biotec.or.th

J Org Chem ; 66(14): 4803-8, 2001 Jul 13.

Article en En | MEDLINE | ID: mdl-11442408

RESUMEN

Bioassay-guided fractionation of the extracts from the insect pathogenic fungus Cordyceps nipponica BCC 1389 led to the isolation of N-hydroxy- and N-methoxy-2-pyridones, cordypyridones A-D (1-4). Structures of these compounds, including absolute configuration, were determined by spectroscopic methods, chemical conversions and single-crystal X-ray diffraction analyses. Codypyridones A and B, atropisomers of each other, exhibited potent in vitro antimalarial activity with IC(50) values of 0.066 and 0.037 microg/mL, respectively, while their cytotoxicity was much weaker.

Asunto(s)

Antimaláricos/química; Hongos/química; Animales; Antimaláricos/aislamiento & purificación; Supervivencia Celular/efectos de los fármacos; Cristalografía por Rayos X; Femenino; Humanos; Concentración 50 Inhibidora; Estructura Molecular; Plasmodium falciparum/efectos de los fármacos; Piridonas/química; Piridonas/aislamiento & purificación; Análisis Espectral; Estereoisomerismo; Células Tumorales Cultivadas

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hongos / Antimaláricos Límite: Animals / Female / Humans Idioma: En Revista: J Org Chem Año: 2001 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Estados Unidos

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