Interleukin levels in cerebrospinal fluid from children with neurocysticercosis.
Am J Trop Med Hyg
; 64(1-2): 35-40, 2001.
Article
en En
| MEDLINE
| ID: mdl-11425160
No information about the levels of pro-inflammatory interleukins has been described in children with neurocysticercosis (NCC). The levels of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-5, IL-6, and IL-12 in the cerebrospinal fluid from children with NCC were determined by enzyme-linked immunosorbent assay (ELISA). Twelve children with NCC, six with active and six with inactive disease, and six children without NCC were studied. TNF-alpha was undetectable in CSF from controls and five children with inactive NCC, whereas the levels were significantly higher (median 22.1 pg/ml; P = 0.008) in all children with active NCC. Levels of IL-6 were low in active and inactive NCC patients but two subjects with active subarachnoid disease had high levels. IL-5 and IL-12 were not detected. This study shows that high levels of TNF-alpha are present in CSF from children with active NCC. IL-6 levels are higher when infection occurs in the subarachnoid space.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Interleucinas
/
Factor de Necrosis Tumoral alfa
/
Neurocisticercosis
Tipo de estudio:
Observational_studies
Límite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Región como asunto:
Mexico
Idioma:
En
Revista:
Am J Trop Med Hyg
Año:
2001
Tipo del documento:
Article
Pais de publicación:
Estados Unidos