Autoimmunity against the ryanodine receptor in myasthenia gravis.

Skeie, G O; Lunde, P K; Sejersted, O M; Mygland, A; Aarli, J A; Gilhus, N E

Skeie, G O; Lunde, P K; Sejersted, O M; Mygland, A; Aarli, J A; Gilhus, N E.

Afiliación

Skeie GO; Department of Neurology, University of Bergen, Bergen, Norway.

Acta Physiol Scand ; 171(3): 379-84, 2001 Mar.

Article en En | MEDLINE | ID: mdl-11412151

RESUMEN

Some myasthenia gravis (MG) patients have antibodies against skeletal muscle antigens in addition to the acetylcholine receptor (AChR). A major antigen for these antibodies is the Ca2+ release channel of the sarcoplasmic reticulum the ryanodine receptor (RyR). These antibodies are found mainly in MG patients with a thymoma MG and correlate with severe MG symptoms. The antibodies recognize a region near the N-terminus on the RyR, which seems to be of importance for RyR regulation. The antibodies cause allosteric inhibition of RyR function in vitro, inhibiting Ca2+ release from sarcoplasmic reticulum.

Asunto(s)

Autoinmunidad; Miastenia Gravis/inmunología; Canal Liberador de Calcio Receptor de Rianodina/inmunología; Animales; Humanos; Inmunosupresores/uso terapéutico; Técnicas In Vitro; Miastenia Gravis/complicaciones; Miastenia Gravis/tratamiento farmacológico; Timoma/complicaciones; Timoma/inmunología; Neoplasias del Timo/complicaciones; Neoplasias del Timo/inmunología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoinmunidad / Canal Liberador de Calcio Receptor de Rianodina / Miastenia Gravis Límite: Animals / Humans Idioma: En Revista: Acta Physiol Scand Año: 2001 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido

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