Mouse models for human familial adenomatous polyposis.

Kucherlapati, R; Lin, D P; Edelmann, W

Kucherlapati, R; Lin, D P; Edelmann, W.

Afiliación

Kucherlapati R; Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. kucherla@aecom.yu.edu

Semin Cancer Biol ; 11(3): 219-25, 2001 Jun.

Article en En | MEDLINE | ID: mdl-11407946

RESUMEN

Colorectal cancer (CRC) is the second most frequent type of cancer in the Western hemisphere. In the United States alone, it is estimated that 150 000 new cases are detected every year and more than 65 000 patients die from complications associated with this cancer. Identification of genes implicated in the initiation and progression of colorectal cancer in humans has prompted the generation of mouse models for this cancer. We will provide a brief overview of these mouse models for CRC and what they have contributed to our understanding of the events involved in the initiation and progression of this cancer.

Asunto(s)

Poliposis Adenomatosa del Colon/genética; Modelos Animales de Enfermedad; Poliposis Adenomatosa del Colon/patología; Animales; Neoplasias Colorrectales/genética; Progresión de la Enfermedad; Humanos; Ratones; Ratones Mutantes

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliposis Adenomatosa del Colon / Modelos Animales de Enfermedad Límite: Animals / Humans Idioma: En Revista: Semin Cancer Biol Asunto de la revista: NEOPLASIAS Año: 2001 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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