Gonadotropin-releasing hormone antagonist: how good is the new hope?
Curr Opin Obstet Gynecol
; 13(3): 257-62, 2001 Jun.
Article
en En
| MEDLINE
| ID: mdl-11396647
Gonadotropin-releasing hormone agonists have been widely used to prevent luteinizing hormone surges during controlled ovarian stimulation in assisted reproductive technologies. Treatment with gonadotropin-releasing hormone agonists of uterine myoma, endometriosis and some hormone-dependent cancers, such as breast, ovarian, endometrial and prostate cancer, also seems to have a beneficial effect. Gonadotropin-releasing hormone agonists have the disadvantage of inducing an initial stimulatory effect on gonadotropin secretion, necessitating 2-3 weeks before pituitary desensitization is achieved. Gonadotropin-releasing hormone antagonists, on the contrary, cause an immediate inhibition of gonadotropin secretion by competitive blocking of pituitary gonadotropin-releasing hormone receptors. Some advantages of their clinical use in controlled ovarian stimulation have already been demonstrated. Randomized comparative studies are needed to investigate their benefit over gonadotropin-releasing hormone antagonists for myoma and hormone-related disorders.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hormona Liberadora de Gonadotropina
/
Infertilidad Femenina
Tipo de estudio:
Clinical_trials
Límite:
Female
/
Humans
Idioma:
En
Revista:
Curr Opin Obstet Gynecol
Asunto de la revista:
GINECOLOGIA
/
OBSTETRICIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Bélgica
Pais de publicación:
Reino Unido