Exploring the potential for subtype-selective muscarinic agonists in glaucoma.

Gil, D; Spalding, T; Kharlamb, A; Skjaerbaek, N; Uldam, A; Trotter, C; Li, D; WoldeMussie, E; Wheeler, L; Brann, M

Gil, D; Spalding, T; Kharlamb, A; Skjaerbaek, N; Uldam, A; Trotter, C; Li, D; WoldeMussie, E; Wheeler, L; Brann, M.

Afiliación

Gil D; Department of Biological Sciences, Allergan, Inc., Irvine, CA 92612, USA. gil_daniel@allergan.com

Life Sci ; 68(22-23): 2601-4, 2001 Apr 27.

Article en En | MEDLINE | ID: mdl-11392632

RESUMEN

Pilocarpine has been used to lower intraocular pressure (IOP) in glaucoma patients for more than 100 years. Since the identification of five muscarinic receptor subtypes, there has been an interest in separating the IOP-lowering effects from the ocular side effects of pupil constriction and lens accommodation. However, all these actions seem to be mediated by the M3 receptor. A novel muscarinic receptor agonist, AGN 199170, that has no activity on the M3 subtype was compared to pilocarpine in a monkey glaucoma model. This compound lowered IOP suggesting that muscarinic agonists targeted at muscarinic receptors other than the M3 subtype may be able to selectively lower IOP.

Asunto(s)

Glaucoma/tratamiento farmacológico; Presión Intraocular/efectos de los fármacos; Agonistas Muscarínicos/farmacología; Agonistas Muscarínicos/uso terapéutico; Pilocarpina/farmacología; Isoformas de Proteínas/metabolismo; Receptores Muscarínicos/metabolismo; Animales; Modelos Animales de Enfermedad; Femenino; Macaca fascicularis

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pilocarpina / Glaucoma / Receptores Muscarínicos / Agonistas Muscarínicos / Isoformas de Proteínas / Presión Intraocular Límite: Animals Idioma: En Revista: Life Sci Año: 2001 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

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