Leitmotifs in the biochemistry of LTP induction: amplification, integration and coordination.

Dineley, K T; Weeber, E J; Atkins, C; Adams, J P; Anderson, A E; Sweatt, J D

Dineley, K T; Weeber, E J; Atkins, C; Adams, J P; Anderson, A E; Sweatt, J D.

Afiliación

Dineley KT; Division of Neuroscience, Baylor College of Medicine, Houston, Texas, USA.

J Neurochem ; 77(4): 961-71, 2001 May.

Article en En | MEDLINE | ID: mdl-11359861

RESUMEN

Hippocampal long-term potentiation (LTP) is a robust and long-lasting form of synaptic plasticity that is the leading candidate for a cellular mechanism contributing to mammalian learning and memory. Investigations over the past decade have revealed that the biochemistry of LTP induction involves mechanisms of great subtlety and complexity. This review highlights themes that have emerged as a result of our increased knowledge of the signal transduction pathways involved in the induction of NMDA receptor-dependent LTP in area CA1 of the hippocampus. Among these themes are signal amplification, signal integration and signal coordination. Here we use these themes as an organizing context for reviewing the profusion of signaling mechanisms involved in the induction of LTP.

Asunto(s)

Hipocampo/fisiología; Potenciación a Largo Plazo/fisiología; Animales; Calcio/fisiología; Retroalimentación; Hipocampo/metabolismo; Modelos Neurológicos; Receptores AMPA/fisiología; Receptores de N-Metil-D-Aspartato/fisiología; Transducción de Señal

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Potenciación a Largo Plazo / Hipocampo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Neurochem Año: 2001 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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