[NO involvement in mediation of spinal neuron sensitization in morphine-withdrawal rats].
Sheng Li Xue Bao
; 53(1): 75-8, 2001 Feb.
Article
en Zh
| MEDLINE
| ID: mdl-11354804
The effects of nitric oxide (NO) on the activation of spinal cord neurons were studied using immunocytochemistry, intrathecal injection and antisense oligonucleotides (AS-ONs) techniques in morphine-withdrawal rats. Acute administration of naloxone and chronic administration of morphine changed neither the expression of Fos-LI and NADPH-d positive neurons nor the expression of Fos/NADPH-d double-labeled neurons in the spinal cord of rats. Fos-LI, NADPH-d positive and Fos/NADPH-d double-labeled neurons were increased significantly in number in morphine-withdrawal rats and they were observed in all the laminae of the spinal cord. Intrathecal injection of L-NA, nNOS antisense oligonucleotides significantly inhibited the expression of Fos-LI in the spinal cord and decreased the scores for morphine-withdrawal symptoms in morphine-withdrawal rats, but not in nNOS-S group. The results suggest that NO mediates the spinal neurons sensitization in morphine-withdrawal rats.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Médula Espinal
/
Síndrome de Abstinencia a Sustancias
/
Morfina
/
Óxido Nítrico
Límite:
Animals
Idioma:
Zh
Revista:
Sheng Li Xue Bao
Año:
2001
Tipo del documento:
Article
Pais de publicación:
China