Dual-release formulation, a novel principle in L-dopa treatment of Parkinson's disease.
Neurology
; 56(9): 1239-42, 2001 May 08.
Article
en En
| MEDLINE
| ID: mdl-11342699
A single morning dose of dual-release formulation was compared with a slow-release formulation of L-dopa plus benserazide in a randomized, double-blind, cross-over study in 16 fluctuating patients with PD. The mean time to "on" was shorter with the dual-release formulation (43 +/- 31 minutes) than with the slow-release formulation (81 +/- 39 minutes) (p < 0.001), whereas the mean time to relapse to "off" was similar for both formulations. The dual-release formulation had a significantly shorter time to reach peak concentration (t(max)) and greater maximum concentration (C(max)) and area under the plasma concentration time curve (AUC(0--5 h)) than the slow-release formulation, whereas apparent elimination half-life (t(1/2)) was similar for both formulations.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Benserazida
/
Levodopa
/
Preparaciones de Acción Retardada
/
Combinación de Medicamentos
Tipo de estudio:
Clinical_trials
Límite:
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Neurology
Año:
2001
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Estados Unidos