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Target site modifications and efflux phenotype in clinical isolates of Streptococcus pneumoniae from Hong Kong with reduced susceptibility to fluoroquinolones.
Ho, P L; Yam, W C; Que, T L; Tsang, D N; Seto, W H; Ng, T K; Ng, W S.
Afiliación
  • Ho PL; Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. plho@hkucc.hku.hk
J Antimicrob Chemother ; 47(5): 655-8, 2001 May.
Article en En | MEDLINE | ID: mdl-11328779
Ciprofloxacin-susceptible (n = 7) and -resistant (MIC >or=4 mg/L) (n = 15) clinical isolates of Streptococcus pneumoniae from diverse sources in Hong Kong were studied for target site modifications and efflux phenotype. Reserpine-inhibited efflux of ciprofloxacin and/or levofloxacin was common in both susceptible and non-susceptible isolates. The ParC substitutions K137N and/or S79F or Y were associated with increased ciprofloxacin MICS. The GyrA substitution S81F was only found in isolates with full resistance to ciprofloxacin (MIC >or=16 mg/L) and levofloxacin (MIC >or=8 mg/L). Among clinical isolates of S. pneumoniae, accumulation of target site mutations in strains with an efflux mechanism was associated with increasing MICs of fluoroquinolones.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Streptococcus pneumoniae / Proteínas Bacterianas / Antiinfecciosos Límite: Humans Idioma: En Revista: J Antimicrob Chemother Año: 2001 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Streptococcus pneumoniae / Proteínas Bacterianas / Antiinfecciosos Límite: Humans Idioma: En Revista: J Antimicrob Chemother Año: 2001 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido