Partial deletions of the long and short arm of chromosome 3 point to two tumor suppressor genes in uveal melanoma.
Cancer Res
; 61(8): 3439-42, 2001 Apr 15.
Article
en En
| MEDLINE
| ID: mdl-11309305
Uveal melanoma is the most common form of primary eye cancer. Monosomy 3, which is an unusual finding in tumors but is present in approximately 50% of uveal melanomas, is significantly correlated with metastatic disease. To obtain positional information on putative tumor suppressor genes on this chromosome, we have investigated tumors from 333 patients by comparative genomic hybridization, microsatellite analysis, or conventional karyotype analysis. A partial deletion of the long arm was found in eight tumors, and the smallest region of deletion overlap (SRO) spans 3q24-q26. We found six tumors with a partial deletion of the short arm and were able to define a second SRO of about 2.5 Mb in 3p25. This SRO does not overlap with the VHL gene. Our finding suggests a role for two tumor suppressor genes in metastasizing uveal melanoma and may explain the loss of an entire chromosome 3 in these tumors.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Úvea
/
Cromosomas Humanos Par 3
/
Genes Supresores de Tumor
/
Deleción Cromosómica
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Proteínas Supresoras de Tumor
/
Ubiquitina-Proteína Ligasas
/
Ligasas
/
Melanoma
Límite:
Humans
Idioma:
En
Revista:
Cancer Res
Año:
2001
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Estados Unidos