[Cyclooxygenases].

Eschwège, P; de Ledinghen, V; Camilli, T; Kulkarni, S; Dalbagni, G; Droupy, S; Jardin, A; Benoît, G; Weksler, B B

[Cyclooxygenases]. / Les cyclooxygénases.

Eschwège, P; de Ledinghen, V; Camilli, T; Kulkarni, S; Dalbagni, G; Droupy, S; Jardin, A; Benoît, G; Weksler, B B.

Afiliación

Eschwège P; Service d'Urologie, Hôpital de Bicêtre, 78, rue du Général Leclerc, F 94270 Le Kremlin-Bicêtre. peschwege@yahoo.com

Presse Med ; 30(10): 511-4, 2001 Mar 17.

Article en Fr | MEDLINE | ID: mdl-11307497

RESUMEN

TWO ISOFORMS: There are two isoforms of cyclooxygenase (COX) with similar structure and metabolic activity. COX-1 is a constitutional enzyme. COX-2 is an inductible form. CYCLOOXYGENASE-1: COX-1 is present in most tissues, particularly in the kidney, the digestive tract mucosa, platelets, brain, liver and spleen. CYCLOOXYGENASE-2: COX-2 expression can be induced by an inflammatory process. Implicated in the development of certain cancers, COX-2 is expressed in numerous tumor cell lines and in most epithelial carcinomas. COX-2 favors tumor invasion and inhibits apoptosis. When it is absent, tumor growth is slower or stopped.

Asunto(s)

Carcinoma/fisiopatología; Transformación Celular Neoplásica; Isoenzimas/metabolismo; Neoplasias Glandulares y Epiteliales/fisiopatología; Prostaglandina-Endoperóxido Sintasas/metabolismo; Apoptosis/efectos de los fármacos; Carcinoma/enzimología; Ciclooxigenasa 1; Ciclooxigenasa 2; Humanos; Proteínas de la Membrana; Invasividad Neoplásica; Neoplasias Glandulares y Epiteliales/enzimología; Células Tumorales Cultivadas

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma / Transformación Celular Neoplásica / Prostaglandina-Endoperóxido Sintasas / Neoplasias Glandulares y Epiteliales / Isoenzimas Límite: Humans Idioma: Fr Revista: Presse Med Año: 2001 Tipo del documento: Article Pais de publicación: Francia

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