Involvement of the neurotensin receptor subtype NTR3 in the growth effect of neurotensin on cancer cell lines.
Int J Cancer
; 92(4): 503-9, 2001 May 15.
Article
en En
| MEDLINE
| ID: mdl-11304684
The expression of the 3 currently known neurotensin receptors was studied in human cancer cells of prostatic, colonic or pancreatic origin by means of RT-PCR analysis and binding experiments. All the cells selected for this work have been shown to exhibit a growth response to neurotensin. We found that the 7 transmembrane domain, levocabastine insensitive receptor (NTR1) is expressed in most but not all of the cells studied whereas the 7 transmembrane domain, levocabastine sensitive receptor (NTR2) is present in none of these cells. The 100 kDa-type I neurotensin receptor (NTR3) is expressed in all the cells assayed. Moreover, we demonstrated that neurotensin can stimulate the growth of CHO cells stably transfected with the NTR3. Taken together, our results strongly suggest that the NTR3 subtype could be involved in the growth response of human cancer cells to neurotensin.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neurotensina
/
Receptores de Neurotensina
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Int J Cancer
Año:
2001
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Estados Unidos