Irritation of gastrointestinal mucosa by new glycosyl derivative of diclofenac in comparison with diclofenac in rats.

Borowiecka, J; Pakulska, W; Graczyk, J; Wagrowska-Danilewicz, M

Borowiecka, J; Pakulska, W; Graczyk, J; Wagrowska-Danilewicz, M.

Afiliación

Borowiecka J; Laborartory of Organic Chemistry, Institute of Chemistry, Chair of Pharmacology, Medical University of Lódz, 90-151 Lódz, 1 Muszynskiego Str., Poland.

Acta Pol Pharm ; 57 Suppl: 99-102, 2000 Nov.

Article en En | MEDLINE | ID: mdl-11293281

RESUMEN

We have obtained new glycosyl derivative of diclofenac 3 and studied its ulcerogenic effect in the gastrointestinal system. Diclofenac as free acid 1 and its derivative 3 were administered to rats per os in a single dose 20 mg/kg and in 5 doses of 5 mg/kg. Single dose of derivative 3 caused less irritation than 1; after multiple administration no irritating effect of derivative 3 was seen.

Asunto(s)

Antiinflamatorios no Esteroideos/toxicidad; Diclofenaco/toxicidad; Mucosa Gástrica/efectos de los fármacos; Mucosa Intestinal/efectos de los fármacos; Irritantes/toxicidad; Animales; Diclofenaco/análogos & derivados; Mucosa Gástrica/patología; Mucosa Intestinal/patología; Masculino; Ratas; Ratas Wistar

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antiinflamatorios no Esteroideos / Diclofenaco / Mucosa Gástrica / Mucosa Intestinal / Irritantes Límite: Animals Idioma: En Revista: Acta Pol Pharm Año: 2000 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Polonia

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