Contribution of CD8(+) T cells to gamma interferon production in human tuberculosis.

Shams, H; Wizel, B; Weis, S E; Samten, B; Barnes, P F

Shams, H; Wizel, B; Weis, S E; Samten, B; Barnes, P F.

Afiliación

Shams H; Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler 75708-3154, USA.

Infect Immun ; 69(5): 3497-501, 2001 May.

Article en En | MEDLINE | ID: mdl-11292783

RESUMEN

The proportions of peripheral blood mononuclear cells (PBMC), CD4(+) T cells, and CD8(+) T cells that produce gamma interferon (IFN-gamma) in response to Mycobacterium tuberculosis were markedly reduced in tuberculosis patients, particularly in those with severe disease. Depletion of CD4(+) but not CD8(+) cells prior to stimulation of PBMC with M. tuberculosis abolished IFN-gamma production. These results show that (i) IFN-gamma production by CD8(+) and CD4(+) cells correlates with the clinical manifestations of M. tuberculosis infection and (ii) IFN-gamma production by CD8(+) cells depends on CD4(+) cells.

Asunto(s)

Linfocitos T CD8-positivos/metabolismo; Interferón gamma/biosíntesis; Tuberculosis/inmunología; Linfocitos T CD4-Positivos/metabolismo; Células Cultivadas; Humanos; Depleción Linfocítica

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis / Interferón gamma / Linfocitos T CD8-positivos Límite: Humans Idioma: En Revista: Infect Immun Año: 2001 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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