Determination of protein-protein interactions of ICIn by the yeast two-hybrid system.
Cell Physiol Biochem
; 11(1): 55-60, 2001.
Article
en En
| MEDLINE
| ID: mdl-11275683
ICln is a ubiquitously expressed eukaryotic protein. Expression of the protein in Xenopus laevis oocytes, the knocking-down of the protein in fibroblasts, or the reconstitution of the protein in lipid bilayer led to the assumption that this protein is an ionic channel or a significant part thereof. However, other possible roles for ICln in potential regulatory mechanisms have been postulated, as diverse as regulator of cell morphology by interacting with the Skb1 protein and/or interaction with core spliceosomal proteins. Here we show that ICln is able to interact with SnRNP core proteins SmD1, SmD2, SmD3, SmX5 and SmB/B'.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Recombinantes de Fusión
/
Proteínas
/
Ribonucleoproteínas Nucleares Pequeñas
/
Técnicas del Sistema de Dos Híbridos
/
Canales Iónicos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Physiol Biochem
Asunto de la revista:
BIOQUIMICA
/
FARMACOLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Austria
Pais de publicación:
Alemania