Bone marrow aplasia induced by passenger leukocytes from heart allografts.
Exp Hematol
; 29(3): 339-44, 2001 Mar.
Article
en En
| MEDLINE
| ID: mdl-11274762
OBJECTIVE: Organ allografts contain passenger leukocytes that are transferred to the recipient with the transplantation, but their functional relevance to the recipient's immune system is still controversial. MATERIALS AND METHODS: To clarify the functional capacity of passenger leukocytes, we attempted to enhance their effect in rat heart allograft recipients by selective depletion of recipient leukocytes using a monoclonal antibody (mAb) against a recipient-specific allotype of CD45 (RT7(a)). RESULTS: Although antibody treatment of the recipient alone led to profound lymphopenia and reversible myelosuppression, additional transplantation of an major histocompatibility complex-incompatible heart graft from an RT7(b) donor led to lethal aplastic anemia in the recipients. This lethal effect was completely abrogated by postoperative anti-CD3 treatment of the recipient and was partially abrogated or delayed by depletion of passenger leukocytes through additional anti-RT7(b) antibody treatment of the recipient or gamma-irradiation of the graft. CONCLUSIONS: The results suggest a role for both donor and recipient-type T cells for the induction of aplastic anemia in this model. The study shows that, under defined conditions, allogeneic passenger leukocytes in a heart graft can have a profound effect on the recipient's immune system and bone marrow.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trasplante Homólogo
/
Médula Ósea
/
Subgrupos de Linfocitos T
/
Trasplante de Corazón
/
Reacción Injerto-Huésped
/
Anemia Aplásica
Límite:
Animals
Idioma:
En
Revista:
Exp Hematol
Año:
2001
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Países Bajos