Sulfated beta-(1-->4)-galacto-oligosaccharides and their effect on angiogenesis.
Carbohydr Res
; 330(3): 427-30, 2001 Feb 15.
Article
en En
| MEDLINE
| ID: mdl-11270823
Sulfated beta-(1-->4)-galacto-oligosaccharides were prepared from an arabino-galacto-rhamno-galacturonan from Lupinus polyphyllus Lindl. by successive partial hydrolysis and SO3-pyridine sulfation in DMF. The resulting oligosaccharide polysulfates were analyzed by analytical GPC and the sulfate content was determined by ion chromatography. DP 5 and higher showed a pronounced antiangiogenic effect with scores of 0.9-1.2 for DP 7-9 using the CAM-assay. An interaction with the fibroblast growth factor FGF-2 was noticed for DP 4-12 depending on the degree of sulfation using the FGF-2-trypsin assay.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oligosacáridos
/
Polisacáridos
/
Neovascularización Fisiológica
/
Inhibidores de la Angiogénesis
Límite:
Animals
Idioma:
En
Revista:
Carbohydr Res
Año:
2001
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Países Bajos