[Speed of ocular saccades in Huntington disease. Prospective study]. / Velocidad de las sacadas oculares en la enfermedad de Huntington. Estudio prospectivo.
Neurologia
; 16(2): 70-3, 2001 Feb.
Article
en Es
| MEDLINE
| ID: mdl-11257932
BACKGROUND: Oculomotor abnormalities, especially slow saccades, have long been recognized in Huntington's disease (HD). OBJECTIVES AND METHODS: To study prospectively horizontal saccade velocity by videonystagmography in 21 patients with genetically confirmed HD. The study included a baseline analysis and a second evaluation after 18.8 +/- 7.1 months. We included a control group of 15 subjects. RESULTS: HD group exhibited decreased saccade velocity when compared with that from a control group (for predictive and unpredictive target). HD patients showed decreased saccade velocity with the passage of time (for predictive target, p < 0.01). Finally we found statistical significant correlation between saccade velocity and triplet length. CONCLUSIONS: The measurement of saccade velocity might be an objective method to study the natural evolution of HD, and thus evaluate the effectiveness of future therapies.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Movimientos Sacádicos
/
Enfermedad de Huntington
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Humans
/
Middle aged
Idioma:
Es
Revista:
Neurologia
Asunto de la revista:
NEUROLOGIA
Año:
2001
Tipo del documento:
Article
Pais de publicación:
España