Presynaptic kainate receptor mediation of frequency facilitation at hippocampal mossy fiber synapses.
Science
; 291(5510): 1972-6, 2001 Mar 09.
Article
en En
| MEDLINE
| ID: mdl-11239159
Inhibition of transmitter release by presynaptic receptors is widespread in the central nervous system and is typically mediated via metabotropic receptors. In contrast, very little is known about facilitatory receptors, and synaptic activation of a facilitatory autoreceptor has not been established. Here we show that activation of presynaptic kainate receptors can facilitate transmitter release from hippocampal mossy fiber synapses. Synaptic activation of these presumed ionotropic kainate receptors is very fast (<10 ms) and lasts for seconds. Thus, these presynaptic kainate receptors contribute to the short-term plasticity characteristics of mossy fiber synapses, which were previously thought to be an intrinsic property of the synapse.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sinapsis
/
Receptores de Ácido Kaínico
/
Transmisión Sináptica
/
Ácido Glutámico
/
Fibras Musgosas del Hipocampo
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos