Treatment with agmatine inhibits Cryptosporidium parvum infection in infant mice.
J Parasitol
; 87(1): 211-3, 2001 Feb.
Article
en En
| MEDLINE
| ID: mdl-11227893
Cryptosporidium parvum is an intracellular protozoan parasite that causes enteric infection and diarrhea in a wide range of mammalian hosts, including humans and economically important livestock species. There are no effective vaccines or drug treatments available for cryptosporidiosis. Cryptosporidium parvum utilizes a unique metabolic pathway for the synthesis of polyamines, forming agmatine as an intermediary metabolite. We treated infant mice with oral doses of agmatine for 2 days before, the day of, and 5 days following experimental infection with C. parvum. Mice treated with agmatine were significantly less infected with C. parvum than were control mice receiving phosphate-buffered saline. Mice treated with agmatine only on the day of experimental infection with C. parvum were also significantly less infected than were control mice. These data suggest that exogenous agmatine alters the metabolism of C. parvum sufficient to interfere with its ability to colonize the mammalian intestine.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cryptosporidium parvum
/
Coccidiostáticos
/
Criptosporidiosis
/
Agmatina
Límite:
Animals
Idioma:
En
Revista:
J Parasitol
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos