Report of a patient with inclusion body myositis and CD8+ chronic lymphocytic leukaemia--post-mortem analysis of muscle and brain.
Acta Neurol Scand
; 103(2): 131-5, 2001 Feb.
Article
en En
| MEDLINE
| ID: mdl-11227133
We report a 73-year-old woman with sporadic inclusion body myositis (s-IBM) and a T-cell chronic lymphocytic leukaemia (T-CLL). The s-IBM diagnosis was based on clinical symptoms and muscle biopsy showing inflammatory infiltrates and rimmed vacuoles with 15 18 nm diameter tubulofilamentous inclusions on ultrastructural examination. The inflammatory infiltrates consisted of CD8+ T-lymphocytes and macrophages. The diagnosis of a CD8+ T-CLL was based on peripheral blood samples and bone marrow aspiration. The postmortem analysis of skeletal muscle showed fascicular atrophy, which may support a neurogenic component in s-IBM and the analysis of the brain showed only a few diffuse plaques in different cortical regions and occasionally neuritic plaques. A pathophysiological analogy between s-IBM and Alzheimer's has been suggested on the basis of similarities in protein accumulation in muscle of s-IBM patients and brain of Alzheimer's patients. However, we were unable to detect any changes suggestive of Alzheimer's disease in the brain of the s-IBM patient presented here.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Leucemia Linfocítica Crónica de Células B
/
Antígenos CD8
/
Músculo Esquelético
/
Miositis por Cuerpos de Inclusión
Límite:
Aged
/
Female
/
Humans
Idioma:
En
Revista:
Acta Neurol Scand
Año:
2001
Tipo del documento:
Article
País de afiliación:
Suecia
Pais de publicación:
Dinamarca