No strong long-term effect of vitamin A supplementation in infancy on CD4 and CD8 T-cell subsets. A community study from Guinea-Bissau, West Africa.
Ann Trop Paediatr
; 20(4): 259-64, 2000 Dec.
Article
en En
| MEDLINE
| ID: mdl-11219162
The World Health Organization recommends that 100,000 IU of vitamin A be given to infants between 6 and 12 months of age at the same time as measles vaccination in order to prevent vitamin A deficiency. In the present study, our aim was to assess the effect of vitamin A supplementation on T-cell subsets in a randomized factorial design, seeking a possible modifying effect of measles vaccination. Three hundred children were allocated either to two doses of measles vaccine at 6 and 9 months of age or to poliomyelitis vaccine at age 6 months and measles vaccine at age 9 months. Within each group, infants were to receive two doses of vitamin A or two doses of placebo at 6 and 9 months of age. We found no significant effect of vitamin A supplementation on CD4 and CD8 T-cell subsets at 3 and 9 months after supplementation. We found no effect of measles vaccine and no interaction between vitamin A supplementation and measles vaccine. Based on these observations, vitamin A supplementation does not seem to have a strong long-term effect on CD4 and CD8 T-cell subsets in infants without clinical vitamin A deficiency.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vitamina A
/
Vacuna Antisarampión
/
Linfocitos T CD4-Positivos
/
Subgrupos de Linfocitos T
/
Linfocitos T CD8-positivos
Tipo de estudio:
Clinical_trials
Límite:
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Ann Trop Paediatr
Año:
2000
Tipo del documento:
Article
País de afiliación:
Dinamarca
Pais de publicación:
Reino Unido