[Glucagon-like peptide 2, a neurotransmitter with a newly discovered role in the regulation of food ingestion]. / Glucagonlignende peptid-2, en neurotransmitter med en nyopdaget rolle i reguleringen af fødeindtagelsen.
Ugeskr Laeger
; 163(3): 287-91, 2001 Jan 15.
Article
en Da
| MEDLINE
| ID: mdl-11219107
We report here that glucagon-like peptide 2(GLP-2) and its receptor constitute a distinct projection system connecting the nucleus of the solitary tract with the dorsomedial hypothalamic nucleus (DMH). The DMH contains a dense plexus of GLP-2 immunoreactive fibres and is the only hypothalamic nucleus expressing GLP-2 receptor mRNA. Consistent with this, central application of GLP-2 activates the expression of neurones solely in the DMH. Furthermore, central administration of GLP-2 causes a dose-related, a pharmacologically and behaviourally specific inhibition of food intake in rats. Surprisingly, the alleged GLP-1 receptor antagonist, Exending (9-39), proved a functional antagonist of centrally applied GLP-2. These data implicate GLP-2 as an important neurotransmitter in the regulation of food intake and likely bodyweight. Our data therefore point to the DMH as a crossroad for endocrine and visceral information affecting feeding behaviour.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptidos
/
Regulación del Apetito
/
Receptores de Glucagón
/
Neurotransmisores
/
Hormonas Gastrointestinales
Límite:
Animals
/
Humans
Idioma:
Da
Revista:
Ugeskr Laeger
Año:
2001
Tipo del documento:
Article
Pais de publicación:
Dinamarca