Importance of attributable risk in monitoring adverse events after immunization: hepatitis B vaccination in children.
Am J Public Health
; 91(2): 313-5, 2001 Feb.
Article
en En
| MEDLINE
| ID: mdl-11211648
OBJECTIVES: Most vaccine safety data present only the postvaccination incidence of all adverse events rather than an estimate of attributable risk. This study sought to illustrate the difference between the 2 estimates with data from a hepatitis B immunization program. METHODS: The incidence of health problems occurring before and after each dose of hepatitis B vaccine in a cohort of 1130 children were compared. RESULTS: Although 47.5% of all children reported an adverse event during the 4 weeks following each of the 3 doses, adverse events attributable to immunization occurred in only 10.6% of children. CONCLUSIONS: Postimmunization incidence systematically overestimates the risk of adverse events. Estimating actual attributable risk is necessary to avoid false beliefs regarding immunization.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vacunas Sintéticas
/
Interpretación Estadística de Datos
/
Monitoreo de Drogas
/
Sistemas de Registro de Reacción Adversa a Medicamentos
/
Vacunas contra Hepatitis B
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Child
/
Humans
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Am J Public Health
Año:
2001
Tipo del documento:
Article
Pais de publicación:
Estados Unidos